578 Improved local drug delivery with bioadhesive nanoparticles in the treatment of skin cancer

Improved i.p. drug delivery with bioadhesive nanoparticles.

The i.p. administration of chemotherapy in ovarian and uterine serous carcinoma patients by biodegradable nanoparticles may represent a highly effective way to suppress peritoneal carcinomatosis. However, the efficacy of nanoparticles loaded with chemotherapeutic agents is currently hampered by their fast clearance by lymphatic drainage. Here, we show that a unique formulation of bioadhesive na...

Bioadhesive Drug Delivery Systems

Cyclodextrin-gantrez Nanoparticles as Bioadhesive Carriers for Oral Drug Delivery

Introduction Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility ...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

Drug Delivery Nanoparticles in Skin Cancers

Nanotechnology involves the engineering of functional systems at nanoscale, thus being attractive for disciplines ranging from materials science to biomedicine. One of the most active research areas of the nanotechnology is nanomedicine, which applies nanotechnology to highly specific medical interventions for prevention, diagnosis, and treatment of diseases, including cancer disease. Over the ...